burn patients infected with metallo-beta-lactamase-producing pseudomonas aeruginosa: multidrug-resistant strains

background metallo-beta-lactamase (mbl) producing pseudomonas aeruginosa in the burn patients is a leading cause of morbidity and mortality and remains a serious health concern among the clinicians. objectives the aim of this study was to detect mbl-producing p. aeruginosa in burn patients and determine multidrug-resistant (mdr) strains, and respective resistance patterns. patients and methods in this cross-sectional study, 270 strains of p. aeruginosa were isolated from the burn patients referred to ghotbeddin burn hospital, shiraz, iran. among them, 55 mbl-producing p. aeruginosa strains were isolated from 55 patients hospitalized in burn unit. minimum inhibitory concentrations (mics) and mbls were determined by the e-test method. results of the 55 burn cases, 29 (53%) were females and 26 (47%) males. injured burn patients’ ages ranged from 16 to 87 years, with maximum number of cases in the age group of 16 to 36 years (n, 40; 72.7%). overall, 32 cases were accidental (60%), and 22 were suicidal burns (40%). of the 55 burn patients, 17 cases were expired (30%). all deaths were due to chemical exposures. in antibiotic susceptibility testing by e-test method, ceftazidime was the most effective one and 35 isolates (63.5%) were resistant to all the 11 tested antibiotics. conclusions routine microbiological surveillance and careful in vitro testing of antibiotics prior to prescription and strict adherence to hospital antibiotic policy may help to prevent, treat, and control mdr and pandrug-resistant (pdr) p. aeruginosa strains in burn units.